on the website**
UCD POST-DOCTORAL RESEARCH FELLOW LEVEL 1
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WHERE TO APPLY
UCD POST-DOCTORAL RESEARCH FELLOW LEVEL 1
APPLICATION DEADLINE: **APPLY ON THE WEBSITE**/**APPLY ON THE
WEBSITE**/**APPLY ON THE WEBSITE**:**APPLY ON THE WEBSITE** -
EUROPE/BRUSSELS
CONTACT DETAILS
WHERE TO SEND YOUR APPLICATION.
Company University College Dublin
* WEBSITE https://
CONTACT TO
HIRING/FUNDING ORGANISATION/INSTITUTE
* ORGANISATION/COMPANY University College Dublin
* ORGANISATION TYPE Higher Education Institute
* WEBSITE https://
* E-MAIL (Please contact us using the "Apply for this Job Posting"
box below)
* COUNTRY Ireland
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* ORGANISATION/COMPANY University College Dublin
* RESEARCH FIELD Medical sciences ? Medicine
* RESEARCHER PROFILE First Stage Researcher (R1)
* APPLICATION DEADLINE **Apply on the website**/**Apply on the
website**/**Apply on the website**:**Apply on the website** -
Europe/Brussels
* LOCATION Ireland ? Dublin
* TYPE OF CONTRACT Temporary
* JOB STATUS Full-time
Applications are invited for a temporary post of a UCD POST-DOCTORAL
RESEARCH FELLOW LEVEL 1 within UCD School of Medicine
Bechet&#**Apply on the website**;s disease (BD) is a heterogeneous
multifactorial auto-inflammatory condition characterised by recurrent
episodes of oral and genital ulceration, uveitis and skin lesions,
with less frequent involvement of the gastrointestinal tract, large
blood vessels and central nervous system. Two recent studies have
reported monogenic mucocutaneous ulcerative syndromes with
similarities to BD, in six
unrelated families caused by loss-of-function mutations in NF-kB
pathway genes.
We have identified 5 Irish families with a very similar illness,
primarily involving childhood-onset chronic oral and genital ulcers.
In the largest, a three generation family, whole exome sequencing
revealed segregation of a mutation in RELA (p**Apply on the website**)
with the condition. The mutation involves a cytosine deletion causing
a His**Apply on the website**ThrfsTer7 frameshift resulting in a
truncated protein of **Apply on the website** amino acids compared
with wild-type RELA of **Apply on the website** amino acids.
Crucially, the mutation interrupts the two C-terminal RELA
transactivating domains.
The research objectives are:
* To determine the biological effects of the RELA His**Apply on the
website**ThrfsTer7 mutation on NF-activities such as inflammation and
apoptosis.
* To use whole exome sequencing to identify potentially causative
mutations in 4 families.
* To undertake appropriate biological studies to determine
genotype-phenotype associations.
This study will give novel information on both the genetic basis and
biological mechanisms of an uncommon, but increasingly recognized
auto-inflammatory condition.
This is a research focused role, where you will conduct a specified
programme of research supported by research training and development
under the supervision and direction of a Principal Investigator. The
primary purpose of the role is to further develop your research skills
and competences, including the processes of publication in
peer-reviewed academic publications, the development of funding
proposals, the mentorship of graduate students along with the
opportunity to develop your skills in research led teaching.
SALARY SCALE: ?**Apply on the website**,**Apply on the website** -
?**Apply on the website**,**Apply on the website** per annum
Appointment on the above range will be dependent on qualifications and
experience
CLOSING DATE: **Apply on the website**:**Apply on the website**hrs
(local Irish time) on **APPLY ON THE WEBSITE**ND JUNE **APPLY ON THE
WEBSITE**
Applications must be submitted by the closing date and time specified.
Any applications which are still in progress at the closing time of
**Apply on the website**:**Apply on the website**hrs (Local Irish
Time) on the specified closing date will be cancelled automatically by
the system. UCD are unable to accept late applications.
UCD do not require assistance from Recruitment Agencies. Any
CV&#**Apply on the website**;s submitted by Recruitment Agencies will
be returned.
ADDITIONAL INFORMATION
WEB SITE FOR ADDITIONAL JOB DETAILS
https:///
REQUIREMENTS
OFFER REQUIREMENTS
SKILLS/QUALIFICATIONS
Higher Education, Research, Medicine
Work location(s) 1 position(s) available at University College Dublin
Ireland Dublin Roebuck Offices
OPEN, TRANSPARENT, MERIT BASED RECRUITMENT PROCEDURES OF RESEARCHERS
(OTM-R)
Know more about it at University College Dublin
Know more about OTM-R
EURAXESS offer ID: **Apply on the website**
Posting organisation offer ID: **Apply on the website**_**Apply on the
website**
share this page Facebook Twitter Linkedin Print this offer
DISCLAIMER:
The responsibility for the jobs published , including the job
description, lies entirely with the publishing institutions. The
application is handled uniquely by the employer, who is also fully
responsible for the recruitment and selection processes.
Please contact if you wish to download all jobs in XML.
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on the website**
UCD POST-DOCTORAL RESEARCH FELLOW LEVEL 1
Where to applyContactSave to favorites
WHERE TO APPLY
UCD POST-DOCTORAL RESEARCH FELLOW LEVEL 1
APPLICATION DEADLINE: **APPLY ON THE WEBSITE**/**APPLY ON THE
WEBSITE**/**APPLY ON THE WEBSITE**:**APPLY ON THE WEBSITE** -
EUROPE/BRUSSELS
CONTACT DETAILS
WHERE TO SEND YOUR APPLICATION.
Company University College Dublin
* WEBSITE https://
CONTACT TO
HIRING/FUNDING ORGANISATION/INSTITUTE
* ORGANISATION/COMPANY University College Dublin
* ORGANISATION TYPE Higher Education Institute
* WEBSITE https://
* E-MAIL (Please contact us using the "Apply for this Job Posting"
box below)
* COUNTRY Ireland
SAVE TO FAVORITES
Please login to use this functionality.
Login
* ORGANISATION/COMPANY University College Dublin
* RESEARCH FIELD Medical sciences ? Medicine
* RESEARCHER PROFILE First Stage Researcher (R1)
* APPLICATION DEADLINE **Apply on the website**/**Apply on the
website**/**Apply on the website**:**Apply on the website** -
Europe/Brussels
* LOCATION Ireland ? Dublin
* TYPE OF CONTRACT Temporary
* JOB STATUS Full-time
Applications are invited for a temporary post of a UCD POST-DOCTORAL
RESEARCH FELLOW LEVEL 1 within UCD School of Medicine
Bechet&#**Apply on the website**;s disease (BD) is a heterogeneous
multifactorial auto-inflammatory condition characterised by recurrent
episodes of oral and genital ulceration, uveitis and skin lesions,
with less frequent involvement of the gastrointestinal tract, large
blood vessels and central nervous system. Two recent studies have
reported monogenic mucocutaneous ulcerative syndromes with
similarities to BD, in six
unrelated families caused by loss-of-function mutations in NF-kB
pathway genes.
We have identified 5 Irish families with a very similar illness,
primarily involving childhood-onset chronic oral and genital ulcers.
In the largest, a three generation family, whole exome sequencing
revealed segregation of a mutation in RELA (p**Apply on the website**)
with the condition. The mutation involves a cytosine deletion causing
a His**Apply on the website**ThrfsTer7 frameshift resulting in a
truncated protein of **Apply on the website** amino acids compared
with wild-type RELA of **Apply on the website** amino acids.
Crucially, the mutation interrupts the two C-terminal RELA
transactivating domains.
The research objectives are:
* To determine the biological effects of the RELA His**Apply on the
website**ThrfsTer7 mutation on NF-activities such as inflammation and
apoptosis.
* To use whole exome sequencing to identify potentially causative
mutations in 4 families.
* To undertake appropriate biological studies to determine
genotype-phenotype associations.
This study will give novel information on both the genetic basis and
biological mechanisms of an uncommon, but increasingly recognized
auto-inflammatory condition.
This is a research focused role, where you will conduct a specified
programme of research supported by research training and development
under the supervision and direction of a Principal Investigator. The
primary purpose of the role is to further develop your research skills
and competences, including the processes of publication in
peer-reviewed academic publications, the development of funding
proposals, the mentorship of graduate students along with the
opportunity to develop your skills in research led teaching.
SALARY SCALE: ?**Apply on the website**,**Apply on the website** -
?**Apply on the website**,**Apply on the website** per annum
Appointment on the above range will be dependent on qualifications and
experience
CLOSING DATE: **Apply on the website**:**Apply on the website**hrs
(local Irish time) on **APPLY ON THE WEBSITE**ND JUNE **APPLY ON THE
WEBSITE**
Applications must be submitted by the closing date and time specified.
Any applications which are still in progress at the closing time of
**Apply on the website**:**Apply on the website**hrs (Local Irish
Time) on the specified closing date will be cancelled automatically by
the system. UCD are unable to accept late applications.
UCD do not require assistance from Recruitment Agencies. Any
CV&#**Apply on the website**;s submitted by Recruitment Agencies will
be returned.
ADDITIONAL INFORMATION
WEB SITE FOR ADDITIONAL JOB DETAILS
https:///
REQUIREMENTS
OFFER REQUIREMENTS
SKILLS/QUALIFICATIONS
Higher Education, Research, Medicine
Work location(s) 1 position(s) available at University College Dublin
Ireland Dublin Roebuck Offices
OPEN, TRANSPARENT, MERIT BASED RECRUITMENT PROCEDURES OF RESEARCHERS
(OTM-R)
Know more about it at University College Dublin
Know more about OTM-R
EURAXESS offer ID: **Apply on the website**
Posting organisation offer ID: **Apply on the website**_**Apply on the
website**
share this page Facebook Twitter Linkedin Print this offer
DISCLAIMER:
The responsibility for the jobs published , including the job
description, lies entirely with the publishing institutions. The
application is handled uniquely by the employer, who is also fully
responsible for the recruitment and selection processes.
Please contact if you wish to download all jobs in XML.
PRIVATE
Please login to access this functionality.
Login / Free Registration
We need : English (Good)
Type: Permanent
Payment:
Category: Others
